Postdoctoral Scientist - Touil Lab - Department of Neurology

Are you ready to be a part of breakthrough research? Take action now by applying to this great opportunity!

Cedars-Sinai offers scientists unparalleled access to ground breaking technologies, facilities, and resources for conducting research related to an impressive range of diseases and disorders, from cancer, cardiology, and digestive diseases, to genetics, genomics, neurosciences, and women's health.

Dr. Hanane Touil invites you to consider this Postdoctoral Scientist opportunity to join her dynamic team!

About the Team

The laboratory of Dr. Touil is part of the Department of Neurology and Biomedical Sciences at Cedars-Sinai in Los Angeles. Dr. Touil leads a translational neuro-immunology research program that integrates rigorous functional neuro-immune assays with ground breaking computational approaches to investigate disease mechanisms underlying neuro-immunological disorders.

Her research focuses on Multiple Sclerosis (MS), compartmentalized inflammation within the central nervous system, and the molecular and cellular signatures of immunosenescence in both healthy aging and Alzheimer’s disease. Using deeply characterized human bio-specimens and advanced analytical methodologies. The laboratory seeks to identify biomarkers associated with prognosis, treatment response, and disease progression in order to advance early diagnosis and precision medicine strategies aimed at halting disease progression.

About the Role

Working independently but in close collaboration and in consultation with Dr. Touil and other Research Scientist in the team, the Postdoctoral Scientist will perform routine and sophisticated laboratory procedures throughout this training period. The candidate will lead a neuro-immunology based project conducting immunologic, transcriptomics and computational based analyses. This role consists in investigating the impact of existing disease modifying therapies on peripheral blood and central nervous based immune signatures during disease progression combining innovative technologies including sc-RNA-seq, CITE-Seq with proteomics and spectral flow cytometry combined with advanced clinical outcomes. The incumbent may develop, adapt, and implement new research techniques and protocols. This position is not responsible for generating grant funds.

Primary Duties and Responsibilities:

• Designs and performs experiments.
• Maintains experimental records and documentation and analyzes the results with the Principal Investigator.
• Analyzes interpret, summarizes, and compiles data.
• Operates and maintains equipment and instruments.
• May observe MD-patient or MD-human research subject interactions as it pertains directly to research being performed.

Department-Specific Duties:

• May collaborate with a multidisciplinary research team, including neurologists, computational biologists, bioengineers, neuroscientists and neuroimaging scientists.
• Process and manage human bio-specimens (Blood, Serum, Plasma, CSF cells and fluid).
• Performs multi-omics (sc-RNA-Seq, Spectral Flow Cytometry and proteomics).
• Implement innovative technologies to validate multi-omic findings.
• Performs functional assays including antigen-presentation, phagocytosis, cytotoxicity and cell proliferation.
• Will screen eligible patients with Multiple Sclerosis, dementia and Alzheimer’s disease ensuring compliance with inclusion and exclusion criteria.
• Follows SOPs and safety laboratory standards.
• Support general laboratory and departmental research activities.
• Assist with junior staff supervision as needed.

Qualifications

Education, Experience, and Skills:

• Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization.
• Ability to work independently and in a collaborative team — and should have excellent organizational and interpersonal skills.
• Acquires technical and theoretical knowledge of research project and objectives during one to five (1-5) year postdoctoral appointment.
• Proficiency in cytometry-related software.
• Experience in human or mouse immunology.
• Experience with completing milestone-driven projects.
• Ability to learn new protocols and platforms.
• Ability to employ computational tools to analyze multi-omics findings.
• Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.
• Knowledge of safety standards and maintenance of specialized equipment.

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About the organization

Cedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents.